Inheritance and Genetics of Autosomal Recessive Polycystic Kidney Disease


advertisement

About inheritance and genetics: Inheritance of Autosomal Recessive Polycystic Kidney Disease refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.

Inheritance of Autosomal Recessive Polycystic Kidney Disease: Autosomal recessive diseases are usually inherited from both parents who are both usually symptom-free genetic carriers (i.e. neither has the disease). See inheritance of autosomal recessive diseases.


Inheritance properties of Autosomal Recessive Polycystic Kidney Disease:
  Disease inherited from: Usually both parents who are symptom-free genetic carriers of Autosomal Recessive Polycystic Kidney Disease; see inheritance of autosomal recessive diseases.
  Gender bias in inheritance: Male or females get the disease equally.
Inheritance odds for Autosomal Recessive Polycystic Kidney Disease:
  Overall odds of inheritance: Usually both parents who are symptom-free genetic carriers of Autosomal Recessive Polycystic Kidney Disease; see inheritance of autosomal recessive diseases.
  Sibling of diseased child odds of inheriting disease: 25% usually for an autosomal recessive disease.
  Inheritance from one diseased parent odds: Usually 0% of disease, 100% of being a genetic carrier if one parent has an autosomal recessive disease (not just carrier).
  Inheritance from two diseased parents odds: 100%. Rare case where both parents are not carriers but actually have the autosomal recessive disease.
Genetic carriers of Autosomal Recessive Polycystic Kidney Disease:
  Inheritance from one carrier parent odds: 0% approximately.
  Inheritance from two carrier parents odds: 25% disease, 50% chance carrier, 25% neither for autosomal recessive diseases.
Inheritance features for Autosomal Recessive Polycystic Kidney Disease:
  Inheritance pattern: Inheritance patterns for autosomal recessive diseases tend to be "horizontal".
  Sporadic form of disease possible?: Very unlikely.

Genetics of Autosomal Recessive Polycystic Kidney Disease: Autosomal recessive PKD is caused by a particular genetic flaw that is different from the genetic flaw that causes autosomal dominant PKD. Parents who do not have the disease can have a child with the disease if both parents carry the abnormal gene and both pass the gene to their baby. The chance of this happening (when both parents carry the abnormal gene) is one in four. If only one parent carries the abnormal gene, the baby cannot get the disease. 1

Footnotes:
1. excerpt from Polycystic Kidney Disease: NIDDK

Medical Tools & Articles:


Next articles:

Medical Articles:
 
 
CureResearch.comTM Copyright © 2010 Health Grades, Inc. All rights reserved.
Home | Contents | Search | Site Map | Feedback | Contact Us | Terms of Use | Privacy Policy | About Us | Advertise