NINDS Muscular Dystrophy (MD) Information Page: NINDS
Article title: NINDS Muscular Dystrophy (MD) Information Page: NINDS
Main condition: Muscular Dystrophy
Conditions: Muscular Dystrophy
What is Muscular Dystrophy (MD)?
Muscular dystrophy (MD) refers to a group of genetic diseases characterized by progressive weakness and degeneration of the skeletal or voluntary muscles which control movement. The muscles of the heart and some other involuntary muscles are also affected in some forms of MD, and a few forms involve other organs as well. The major forms of MD include myotonic, Duchenne, Becker, limb-girdle, facioscapulohumeral, congenital, oculopharyngeal, distal and Emery-Dreifuss. Duchenne is the most common form of MD affecting children, and myotonic MD is the most common form affecting adults. MD can affect people of all ages. Although some forms first become apparent in infancy or childhood, others may not appear until middle age or later.
Is there any
treatment?
There is no specific treatment for any of the forms of
MD. Physical therapy to prevent contractures (a condition in which
shortened muscles around joints cause abnormal and sometimes painful
positioning of the joints), orthoses (orthopedic appliances used for
support) and corrective orthopedic surgery may be needed to improve the
quality of life in some cases. The cardiac problems that occur with
Emery-Dreifuss MD and myotonic MD may require a pacemaker. The myotonia
(delayed relaxation of a muscle after a strong contraction) occurring in
myotonic MD may be treated with medications such as phenytoin or quinine.
What is the prognosis?
The
prognosis of MD varies according to the type of MD and the progression of
the disorder. Some cases may be mild and very slowly progressive, with
normal lifespan, while other cases may have more marked progression of
muscle weakness, functional disability and loss of ambulation. Life
expectancy may depend on the degree of progression and late respiratory
deficit. In Duchenne MD, death usually occurs in the late teens to early
20s.
What research is being
done?
The NINDS supports a broad program of research on MD. The
goals of these studies are to increase understanding of MD and its
cause(s), develop better therapies, and, ultimately, find ways to prevent
and cure the disorder.
Facioscapulohumeral Dystrophy (FSHD) Society
3 Westwood Road
Lexington, MA 02420
info@fshsociety.org
http://www.fshsociety.org/
Tel:
781-860-0501
Fax: 781-860-0599
Muscular Dystrophy Association
3300 East Sunrise Drive
Tucson, AZ 85718-3208
mda@mdausa.org
http://www.mdausa.org/
Tel:
520-529-2000 800-572-1717
Fax: 520-529-5300
Muscular Dystrophy Family Foundation
2330 North Meridien
Street
Indianapolis, IN 46208
mdff@mdff.org
http://www.mdff.org/
Tel: 317-923-6333
800-544-1213
Fax: 317-923-6334
Parent Project for Muscular Dystrophy Research
1012 North
University Blvd.
Middletown, OH 45042
ParentProject@aol.com
http://www.parentprojectmd.org/
Tel:
413-424-0696 800-714-KIDS (5437)
Fax: 513-425-9907
Related NINDS Publications and Information
Summary of a May 2000 NINDS workshop on
Duchenne muscular dystrophy.
Summary of a conference, "The Cause and
Treatment of Facioscapulohumeral Muscular Dystrophy," held May 8-9,
2000.
Congressional testimony on muscular dystrophy by Dr.
Audrey Penn, Acting Director, NINDS, February 2001.
This fact sheet is in the public domain. You may copy it.Provided
by:
The National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD
20892
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