Inheritance and Genetics of Hemophilia
| About inheritance and genetics: Inheritance of Hemophilia refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics. |
Inheritance of Hemophilia: X-linked recessive diseases are usually inherited by males from their mother. Rare cases of sporadic genetic disease can also occur. See inheritance of x-linked recessive diseases.
Inheritance properties of Hemophilia:
Disease inherited from: Usually inherited by males from their mother who is a carrier; see inheritance of x-linked recessive diseases.
Gender bias in inheritance: Males only get x-linked recessive diseases; females are carriers.
Inheritance odds for Hemophilia:
Overall odds of inheritance: Usually inherited by males from their mother who is a carrier; see inheritance of x-linked recessive diseases.
Sibling of diseased child odds of inheriting disease: About 50% for a second child if one (male) child already has the x-linked recessive disease.
Mother to son inheritance odds: 50% disease, 50% disease-free, males cannot be a carrier of an x-linked recessive disease.
Father to son inheritance odds: 0% chance usually for x-linked recessive diseases.
Mother to daughter inheritance odds: 0% disease; 50% female carrier, 50% chance neither affected nor carrier.
Father to daughter inheritance odds: 0% chance of x-linked recessive disease; 100% chance the female child is a carrier.
Inheritance features for Hemophilia:
Sporadic form of disease possible?: Yes, requires single mutation for x-linked recessive disease.
Milder form of disease possible in females?: Yes, females have mild disease for some x-linked recessive diseases.
Last revision: May 28, 2003
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