Conditions by People Affected (Prevalence or Incidence)


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Conditions here are listed by a combined measure of either prevalence or incidence. This gives an approximate measure of the "people affected" by the condition in any year. Prevalence refers to the total pool of people affected, whereas incidence is the annual number of new cases. Lifelong diseases like diabetes can have a low incidence but a large cumulative prevalence count, whereas short-lived diseases like flu can have a high incidence but a low prevalence. For comparison between prevalence and incidence rates see also our conditions by prevalence and conditions by incidence. See also details about prevalence and incidence statistics for more information.

In most cases, the prevalence counts and incidence rates refer to the USA or other industrialized nations. Our estimates show 268 conditions affecting a million or more Americans, 162 conditions between 100,000 and a million, and 1685 conditions of less than 100,000 US people.

Condition Percent Rate US People Data
1. Diarrhea 100.00% 1 in 1 272 million almost 100% annually (NIDDK)
2. Common Headache 90.00% 1 in 1 244.8 million 90% approximately; almost everyone gets some each year.
3. Respiratory conditions 78.90% 1 in 1 214.6 million 78.9 per 100 (NHIS96)
4. Dental caries 55.57% 1 in 2 151.2 million 2,534,161 annual cases in Victoria 1996 (DHS-VIC)
5. Cytomegalovirus 50.00% 1 in 2 136 million 50% approximately; almost half of young adults (NIAID)
6. Cold sores 50.00% 1 in 2 136 million estimated 50 to 80% of Americans have HSV-1
7. Refractive Eye Disorders 44.12% 1 in 2 120 million 120 million people
8. High Cholesterol 37.13% 1 in 3 101 million estimated 101 million Americans have cholesterol >= 200 mg/dL (CDC)
9. Infectious Diarrhea 36.40% 1 in 3 99 million 99 million new cases in the USA 1980 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
10. Flu 36.00% 1 in 3 97.9 million 36 per 100 (NHIS96); 35 million annually up to 50 million annually (NIAID/CDC); 10-20% yearly (NIAID)
11. Overweight 35.70% 1 in 3 97.1 million 97.1 million American adults
12. Chronic Illness 33.09% 1 in 3 90 million 90 million people in USA (CDC)
13. Food poisoning 27.94% 1 in 3 76 million about 76 million cases annually in USA (NIDDK)
14. Myopia 25.74% 1 in 3 70 million 70 million Americans; over 25 percent of all adult Americans.
15. Insulin Resistance 25.00% 1 in 4 68 million about 25% of the USA population have insulin resistance
16. Metabolic Syndrome 25.00% 1 in 4 68 million about 25% of the USA population have insulin resistance
17. Genital herpes 24.63% 1 in 4 67 million 67 million people (NIAID)
18. Sexually Transmitted Diseases 23.90% 1 in 4 65 million 65 million people living with an incurable STD (CDC)
19. Common cold 22.79% 1 in 4 62 million 62 million cases (NIAID); 23.6 per 100 (NHIS96); estimated 1 billion colds in the USA annually; Children get 6-10 yearly, adults 2-4 yearly; over 60's less than 1 a year.
20. Cardiovascular diseases 22.72% 1 in 4 61.8 million 61,800,000 cases in the USA (American Heart Association, 2004)
21. Hyperopia 22.40% 1 in 4 60.9 million 22.4% of population self-reported having long-sightedness in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW)
22. Smoking 22.30% 1 in 4 60.7 million 22.3% of Americans smoke (CDC); 23 million American women smoke (NHLBI)
23. Mental illness 22.10% 1 in 4 60.1 million about 22.1 percent of American adults annually or 44.3 million people (NIMH)
24. Toxoplasmosis 22.06% 1 in 4 60 million More than 60 million in USA but few have symptoms (DPD)
25. Digestive Diseases 22.06% 1 in 4 60 million 60 to 70 million cases in the USA 1985 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447)
26. Injury 21.69% 1 in 4 59 million 59 million cases (IOM)
27. Epstein-Barr virus 20.00% 1 in 5 54.4 million as many as 20% of people carry the virus in their throats
28. Hypertension 18.38% 1 in 5 50 million 50 million Americans (NHLBI); 217 per 1000 (NHIS95)
29. Dandruff 18.38% 1 in 5 50 million 50 million
30. Allergies 18.38% 1 in 5 50 million 50-60 million (NIAID); 9-16% (NIAID); 50 million cases annually (NIAID); 10% of American women (NHWIC); 8,526,000 children respiratory allergies (NHIS-97); 7,304,000 children non-respiratory allergies (NHIS-97)
31. Headache 16.54% 1 in 6 45 million 45 million Americans get chronic headaches. 20 million American women (NWHIC).
32. Chronic headache 16.54% 1 in 6 45 million estimated 45 million Americans (NINDS)
33. Astigmatism 16.54% 1 in 6 45 million 45 million Americans (dubious estimate based on "two thirds of people with myopia also have astigmatism")
34. Anxiety Disorders 16.40% 1 in 6 44.6 million estimated 16.4% adults (USSG); 19.1 million American adults (NIMH); 13.3% of adults (NIMH)
35. Impaired glucose tolerance 15.07% 1 in 6 41 million estimated 41 million people aged 40-74 have pre-diabetes in the US 1988-94 (National Diabetes Statistics fact sheet, NIDDK, 2003)
36. Premenstrual syndrome 15.00% 1 in 6 40.8 million 30-40% women suffer some impairment of daily activity (NWHIC); 75% women have some symptoms; 3-8% women have severe PMS (NWHIC).
37. Hives 15.00% 1 in 6 40.8 million about 15% Americans each year (NWHIC)
38. Orthopedic disorders 14.90% 1 in 6 40.5 million 149 per 1000 - NHIS95
39. Sleep disorders 14.71% 1 in 6 40 million approximately 40 million Americans (NHLBI)
40. Obesity 14.63% 1 in 6 39.8 million 39.8 million American adults; more than 57% of American adults are overweight (CDC)
41. Arthritis 13.60% 1 in 7 37 million 37 million Americans (NIAMS)
42. Sinusitis 13.60% 1 in 7 37 million 37 million annually in the USA; 33 million reported to CDC (NIAID)
43. Hay fever 12.87% 1 in 7 35 million 35 million Americans (NIAID: pollen allergies)
44. Pollen allergy 12.87% 1 in 7 35 million estimated 35 million Americans with pollen allergies (NIAID)
45. Chronic Sinusitis 12.83% 1 in 7 34.9 million 12.6% (NIAID); 152 per 1000 - NHIS95
46. Insomnia 11.76% 1 in 8 32 million 32 million (unreliable estimate)
47. Chronic lower respiratory diseases 11.76% 1 in 8 32 million estimated 32 million including 15 million undiagnosed
48. Lung conditions 11.03% 1 in 9 30 million more than 30 million Americans with chronic lung diseases (NWHIC)
49. Impotence 11.03% 1 in 9 30 million 30 million men (NIDDK)
50. Lactose Intolerance 11.03% 1 in 9 30 million 30 million people to 50 million people (NIDDK 1994); about 25% of population (1994/NIDDK)
51. Osteoporosis 10.29% 1 in 9 28 million 28 million Americans (10 million with osteoporosis; 18 million with low bone mass); eight million American women and 2 million men (NWHIC)
52. Migraine 10.29% 1 in 9 28 million 28 million Americans (NINDS)
53. Moles 10.00% 1 in 10 27.2 million common; most people have 10-40 moles.
54. Molluscum contagiosum 10.00% 1 in 10 27.2 million Common.
55. Scabies 10.00% 1 in 10 27.2 million common
56. Retroverted uterus 10.00% 1 in 10 27.2 million about 1 in 5 women
57. Subfertility 10.00% 1 in 10 27.2 million about 1 in 10 couples
58. Allergic rhinitis 10.00% 1 in 10 27.2 million 10% of the population with allergic rhinitis/hay fever in the US (Mayo Clinic)
59. Otosclerosis 10.00% 1 in 10 27.2 million as many as 10% of Caucasians have the condition but most do not get symptoms; about 1 in 100 cases actually lose hearing from otosclerosis
60. Extra Nipples 10.00% 1 in 10 27.2 million about 1 in 10 people but most are small and mistaken for freckles or moles
61. Depressive disorders 9.50% 1 in 10 25.8 million 9.5 percent of adult Americans (NIMH)
62. Rare diseases 9.19% 1 in 10 25 million about 25 million Americans (ORD); each disease less than 200,000 Americans by definition.
63. Presbyopia 9.00% 1 in 11 24.5 million 9.0% of population self-reported having presbyopia in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW)
64. Back Impairment 8.50% 1 in 11 23.1 million 85 per 1000 - NHIS95 (deformity or orthopedic impairment of back)
65. Heart disease 8.09% 1 in 12 22 million 22 million adults in the US 2000 (Centers for Disease Control and Prevention)
66. Hearing Impairment 8.09% 1 in 12 22 million 22 million; 158 per 1000 (NHIS95)
67. Thyroid disorders 7.35% 1 in 13 20 million 20 million Americans (NWHIC)
68. Human Papillomavirus 7.35% 1 in 13 20 million 20 million Americans currently infected (NIAID; CDC 2001)
69. Osteoarthritis 7.35% 1 in 13 20 million 20 million people (NIAMS); more than 16 million people (NWHIC)
70. Mood disorders 7.10% 1 in 14 19.3 million estimated 7.1% adults (USSG)
71. Ischemic heart disease 6.80% 1 in 14 18.5 million 68 per 1000 (NHIS95)
72. Sleep apnea 6.62% 1 in 15 18 million estimated 18 million Americans (NHLBI)
73. Asthma 6.40% 1 in 15 17.4 million 6.4% USA (NIAID); 17 million Americans (NIAID) including 5 million children; 8.1 million children (NHIS-97), 51 per 1000 - NHIS95; 14.5 million; 5% of population (NWHIC); 14.9 million in 1995 (NHLBI)
74. Acne 6.25% 1 in 16 17 million 17 million Americans, almost 85% of people 12-24 years of age.
75. Diabetes 5.88% 1 in 17 16 million 16 million Americans with 10.3 million diagnosed and 8.1 million women (NWHIC); 65 per 1000 - NHIS95; 8 million - perhaps 16 million if include not-yet-diagnosed.
76. Type 2 diabetes 5.88% 1 in 17 16 million 16 million Americans (NWHIC, includes undiagnosed); 7.2 million (actually diagnosed)
77. Gallstones 5.88% 1 in 17 16 million 16 to 22 million people in the USA 1976-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, US Government Printing Office, NIDDK, 1994)
78. Alcoholism 5.55% 1 in 18 15.1 million estimated 15.1 million people: 15.1 million alcohol-abusing or alcohol-dependent individuals and 4.6 million are women (NWHIC); nearly 14 million Americans (NIAAA)
79. Alcohol abuse 5.55% 1 in 18 15.1 million estimated 15.1 million people: 15.1 million alcohol-abusing or alcohol-dependent individuals and 4.6 million are women (NWHIC); nearly 14 million Americans (NIAAA)
80. Eczema 5.51% 1 in 18 15 million 15 million people (NIAMS); 10% infants/children estimated (NIAMS); 9% (NIAID); 8.5 million
81. Gynecomastia 5.51% 1 in 18 15 million 15 million - 15% of adult men to some extent (unreliable estimate)
82. Heartburn 5.51% 1 in 18 15 million 15 million Americans have it daily (NIDDK)
83. Depression 5.30% 1 in 18 14.4 million estimated 5.3% adults (USSG); 17 million people; approximately 4% of adolescents get seriously depressed (NIMH); annually 12% of women ; 7% of men; lifetime risk of an episode for women 20%. 3-4 million men USA.
84. Arrhythmias 5.30% 1 in 18 14.4 million 53 per 1000 (NHIS95: heart rhythm disorders); 21 per 1000 (NHIS95: heart murmurs)
85. Urinary stones 5.20% 1 in 19 14.1 million 5.2% of adults in the USA 1988-1994 (Weighted Analysis of 1988-1994 National Health and Nutrition Survey, 2003)
86. Raynaud's phenomenon 5.00% 1 in 20 13.6 million 5-10% (NIAMS estimate). Scleroderma-related disorders including Raynaud's phenomenon between 250,000 and 992,500.
87. Uterine fibroids 5.00% 1 in 20 13.6 million 10-20% women (NWHIC)
88. Endometriosis 5.00% 1 in 20 13.6 million 10 to 20 percent of American women of childbearing age have endometriosis (NIDCD); up to 2 million women in the UK.
89. Red-green color blindness 5.00% 1 in 20 13.6 million about 10% of males
90. Chronic Obstructive Pulmonary Disease 4.96% 1 in 20 13.5 million 13.5 million Americans (NHLBI)
91. Coronary heart disease 4.85% 1 in 20 13.2 million estimated 13,200,000 in the USA 2001 (American Heart Association, 2004)
92. Urinary Incontinence 4.78% 1 in 20 13 million 13 million adults (NIDDK); 1 in 10 over 65 (NWHIC).
93. Rosacea 4.78% 1 in 20 13 million 13 million people in the United States (NIAMS)
94. Acute Bronchitis 4.60% 1 in 21 12.5 million 4.6 per 100 (NHIS96: acute bronchitis); 14.2 million cases annually
95. Varicose veins 4.50% 1 in 22 12.2 million 45 per 1000 (NHIS95)
96. Tinnitus 4.50% 1 in 22 12.2 million 45 per 1000 (NHIS95); 12 million Americans
97. Chronic Bronchitis 4.45% 1 in 22 12.1 million 12.1 million Americans (NHLBI)
98. Obstructive sleep apnea 4.41% 1 in 22 12 million 12 million Americans
99. Genetic Disease 4.41% 1 in 22 12 million 12 million Americans - unreliable estimate, (perhaps 2.5% births)
100. Phobias 4.23% 1 in 23 11.5 million 11.5 million adults (NIMH); 8.0% adults (NIMH)
101. Iron deficiency anemia 4.12% 1 in 24 11.2 million 187,979 annual cases in Victoria 1996 (DHS-VIC); 20% women of childbearing age; 2% adult men (NWHIC)
102. Cornea disorders 4.04% 1 in 24 11 million 11,000,000 people experience corneal disorders such as herpes or dry eye in the US (Research to Prevent Blindness, NISE, NSF)
103. Dysthymia 4.01% 1 in 24 10.9 million about 10.9 million American adults (NIMH); estimated 1.6% adults (USSG)
104. Presbycusis 3.90% 1 in 25 10.6 million 30-35% over 65 have some hearing loss, 40-50% over 70.
105. Hemorrhoids 3.82% 1 in 26 10.4 million 10.4 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
106. Social phobia 3.70% 1 in 27 10.1 million 5.3 million adult Americans (NIMH); 3.7% adults (NIMH); 2.0% adults (USSG)
107. Latent tuberculosis 3.68% 1 in 27 10 million estimated 10 to 15 million people in USA (NIAID)
108. Jaw conditions 3.68% 1 in 27 10 million estimated 10 million women in the USA (NWHIC)
109. Traveler's diarrhea 3.68% 1 in 27 10 million estimated 10 million (DBMD)
110. Enteroviruses 3.68% 1 in 27 10 million estimated 10-15 million cases annually in USA (DVRD)
111. Age-related macular degeneration 3.68% 1 in 27 10 million 10,000,000 people have reduced vision due to age-related macular degeneration in the US (Research to Prevent Blindness, NISE, NSF)
112. Post-traumatic stress disorder 3.60% 1 in 27 9.8 million 5.2 million adult Americans (NIMH); 3.6% adults (NIMH); about 30% of war veterans.
113. Indigestion 3.50% 1 in 28 9.5 million 35 per 1000 - NHIS95 (frequent indigestion)
114. Dermatitis 3.30% 1 in 30 8 million 33 per 1000 (NHIS95)
115. Insect sting allergies 3.30% 1 in 30 8 million 3.3% (NIAID); up to 5% of the population (NHWIC)
116. Bursitis 3.20% 1 in 31 8.7 million 32 per 1000 (NHIS95)
117. Autoimmune diseases 3.13% 1 in 31 8.5 million 8,511,845 people in the USA 1996 1
118. Dry skin 3.10% 1 in 32 8.4 million 31 per 1000 - NHIS95 (trouble with dry/itching skin)
119. Disc Disorders 3.10% 1 in 32 8.4 million 31 per 1000 (NHIS95: intervertebrate disc disorders)
120. Acute urinary conditions 3.09% 1 in 32 8.4 million 8.405 million new conditions (NIDDK)
121. Acute Nonulcer dyspepsia 3.01% 1 in 33 8.2 million 8.2 million new cases (1988/NIDDK)
122. Paget's disease of bone 3.00% 1 in 33 8.2 million about 3% of people aged over 40; 10% by age 80.
123. Congenital conditions 3.00% 1 in 33 8.2 million 3-4% of babies (NWHIC)
124. Gastroesophageal Reflux Disease 3.00% 1 in 33 8.2 million 3-7% of the population in the USA 1985 for "GERD and related esophageal disorders" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
125. Urinary tract infections (child) 3.00% 1 in 33 8.2 million 3% of girls and 1% of boys before age 11
126. Cerebrovascular Conditions 3.00% 1 in 33 8.2 million 30 per 1000 - NHIS95
127. Generalized anxiety disorder 2.80% 1 in 35 7.6 million 4 million adult Americans (NIMH); 2.8% adults (NIMH); estimated 3.4% adults (USSG)
128. Heart attack 2.76% 1 in 36 7.5 million 7.5 million people with AMI (NHLBI)
129. Squint 2.76% 1 in 36 7.5 million 7,500,000 people suffer from strabismus or cross eyes in the US (Research to Prevent Blindness, NISE, NSF)
130. Kidney disease 2.72% 1 in 36 7.4 million 7.4 million adults in the USA 1988-94 (American Journal of Kidney Disease)
131. Prostate conditions 2.60% 1 in 38 7.1 million 52 per 1000 men - NHIS95; 2,803 million men (NIDDK)
132. Ingrown nails 2.60% 1 in 38 7.1 million 26 per 1000 - NHIS95 (trouble with ingrown nails)
133. Middle ear infection 2.57% 1 in 38 7 million 7 million annually
134. Callus 2.50% 1 in 40 6.8 million 25 per 1000 - NHIS95 (trouble with corns or calluses)
135. Corns 2.50% 1 in 40 6.8 million 25 per 1000 - NHIS95 (trouble with corns or calluses)
136. Polycystic ovary syndrome 2.50% 1 in 40 6.8 million 5-10% women of childbearing age (20-40); 30% of women have some PCOS symptoms (NWHIC).
137. Fecal incontinence 2.39% 1 in 41 6.5 million 6.5 million Americans
138. Angina 2.35% 1 in 42 6.4 million 6.4 million Americans (NHLBI)
139. Specific phobias 2.32% 1 in 43 6.3 million estimated 6.3 million adult Americans (NIMH); estimated 8.3% adults (USSG)
140. Occupational Injuries 2.32% 1 in 43 6.3 million 6.3 million workers in 1994 (CDC-OC)
141. Obsessive-compulsive disorder 2.30% 1 in 43 6.3 million 3.3 million adult Americans (NIMH); 2.3% adults (NIMH); 1 in 50 people (NWHIC); 2.4% adults (USSG)
142. Cystitis 2.28% 1 in 43 6.2 million 6.2 million adults self-reported having a bladder infection for more than 3 months in the US 1988-1994 (Weighted Analysis of 1988-1994, NHANES, NIDDK)
143. Infertility 2.24% 1 in 44 6.1 million 6.1 million people in 1997 (NWHIC); 5.3 million Americans or 9% of reproductive age (NWHIC/American Society for Reproductive Medicine)
144. Back pain 2.21% 1 in 45 6 million 6 million cases annually (unreliable estimate)
145. Chest pain 2.21% 1 in 45 6 million 6 million cases annually (unreliable estimate)
146. Nonulcer dyspepsia 2.13% 1 in 46 5.8 million 5.8 million people in the USA 1988 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, 1994)
147. Anti-Social Personality Disorder 2.10% 1 in 47 5.7 million estimated 2.1% adults (USSG)
148. Periodontitis 2.07% 1 in 48 5.6 million 94,482 annual cases in Victoria 1996 (DHS-VIC)
149. Cataracts 2.02% 1 in 49 5.5 million 5,500,000 people have a cataract interfering with their vision in the US (Research to Prevent Blindness, NISE, NSF)
150. Psoriasis 2.02% 1 in 49 5.5 million 5.5 million people in the USA (NIAMS)
151. Autoimmune thyroid diseases 2.00% 1 in 50 5.4 million 4 out of 100 women some type of autoimmune thyroid disease
152. Borderline Personality Disorder 2.00% 1 in 50 5.4 million 2 percent of adults (NIMH)
153. Cyclic vomiting syndrome 2.00% 1 in 50 5.4 million 1 in 50 children (perhaps)
154. Penicillin allergy 2.00% 1 in 50 5.4 million 2-3% of people (2-3% of hospitalized patients)
155. Mitral-valve prolapse 2.00% 1 in 50 5.4 million 2% of the adult population (NHLBI estimate)
156. Bunions 1.92% 1 in 51 5.2 million 19.25 per 1000 - NHIS95 (trouble with bunions)
157. Female genital disorders 1.90% 1 in 52 5.2 million 38 per 1000 women (NHIS95)
158. Trichomoniasis 1.84% 1 in 54 5 million 5 million cases annually in the USA (CDC 2001)
159. Irritable bowel syndrome 1.84% 1 in 54 5 million 5 million in the USA 1987 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, US Government Printing Office, 1994); 11 per 1000 (NHIS95)
160. Peptic Ulcer 1.84% 1 in 54 5 million 5 million in the USA 1987 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, 1994)
161. Eating disorders 1.84% 1 in 54 5 million 5 million women (NWHIC); 1-4% of young women
162. Pneumonia 1.76% 1 in 56 4.8 million 4.8 million annual cases (1996); 1.8 per 100 (NHIS96)
163. Heart failure 1.76% 1 in 56 4.8 million 4.8 million (NHLBI); 2 to 3 million Americans (NHLBI)
164. Congestive Heart Failure 1.76% 1 in 56 4.8 million 4.8 million Americans (NHLBI); 2% age 40-59; 5% age 60-69; 10% over 70's
165. Panic disorder 1.70% 1 in 58 4.6 million approximately 2.4 million Americans (NIMH)
166. Atherosclerosis 1.70% 1 in 58 4.6 million 17 per 1000 - NHIS95
167. Learning disabilities 1.69% 1 in 59 4.6 million 4.6 million children (NHIS-97)
168. Stroke 1.69% 1 in 59 4.6 million estimated 4.6 million (NHLBI)
169. Automobile accidents injury 1.68% 1 in 59 4.6 million 4,563,000 cases requiring emergency department visits in 2000 (CDC)
170. Abdominal Hernia 1.65% 1 in 60 4.5 million 4.5 million people in the USA 1988-90 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
171. Constipation 1.62% 1 in 61 4.4 million 4.4 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
172. Edema 1.60% 1 in 62 4.4 million 1.6% of population self-reported having oedema in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW)
173. Tachycardia 1.60% 1 in 62 4.4 million 16 per 1000 (NHIS95)
174. Falls 1.52% 1 in 65 4.1 million 69,264 annual cases in Victoria 1996 (DHS-VIC)
175. Kidney conditions 1.50% 1 in 66 4.1 million 15 per 1000 (NHIS95: "kidney trouble")
176. Undescended Testicle 1.50% 1 in 66 4.1 million 3% of male babies; about 30% of premature male babies.
177. Childbirth 1.49% 1 in 67 4 million 4,043,000 annual live births ending Aug 2001 (NVSR 50:7 2002); 4,058,814 annually in 1999 in USA (CDC)
178. Shoulder conditions 1.47% 1 in 68 4 million about 4 million annual cases in USA (NIAMS)
179. Alzheimer's Disease 1.47% 1 in 68 4 million more than 4 million Americans (CDC); estimated 4 million people in the U.S (NHWIC)
180. Chlamydia 1.47% 1 in 68 4 million estimated 4 million cases (NIAID/CDC) [4-8 million cases] including undiagnosed (about 600,000 diagnosed).
181. Pregnancy 1.47% 1 in 68 4 million more than 4 million; 1 million adolescent U.S. females become pregnant every year
182. Drug abuse 1.47% 1 in 68 4 million more than 4 million women need treatment for drug abuse (NWHIC)
183. Chronic Hepatitis C 1.47% 1 in 68 4 million Almost 4 million Americans have antibodies indicating infection or prior exposure (NIDDK).
184. Deafness 1.47% 1 in 68 4 million 4 million people (unreliable estimate)
185. Fibromyalgia 1.36% 1 in 73 3.7 million 3.7 million Americans (NIAMS)
186. Open Wound 1.32% 1 in 75 3.6 million 60,052 annual cases of open wounds in Victoria 1996 (DHS-VIC)
187. Color blindness 1.30% 1 in 76 3.5 million 13 per 1000 - NHIS95
188. Anemia 1.29% 1 in 77 3.5 million 3.5 million (NHLBI)
189. Attention Deficit Hyperactivity Disorder 1.21% 1 in 82 3.3 million 3.3 million children have ADD in USA (NHIS-97); estimated 2 million American children; 3 to 5 percent of all children (NIMH).
190. Rheumatic fever 1.20% 1 in 83 3.3 million 12 per 1000 (NHIS95)
191. Bipolar disorder 1.20% 1 in 83 3.3 million 1.2 percent of the population; 2.3 million adult Americans (NIMH)
192. Colitis 1.20% 1 in 83 3.3 million 12 per 1000 (NHIS95: "enteritis or colitis")
193. Enteritis 1.20% 1 in 83 3.3 million 12 per 1000 (NHIS95: "enteritis or colitis")
194. Acute rheumatic fever 1.20% 1 in 83 3.3 million 12 per 1000 (NHIS95)
195. Agoraphobia 1.18% 1 in 84 3.2 million approximately 3.2 million American adults ages 18 to 54 (NIMH); estimated 4.9% adults (USSG)
196. Bladder conditions 1.15% 1 in 86 3.1 million 3.139 million cases (chronic, NIDDK); 25 per 1000 - NHIS95 (bladder disorders)
197. Graves Disease 1.12% 1 in 89 3 million 3,048,636 people in the USA 1996 1; 1.3 million people (NWHIC)
198. Pubic lice 1.10% 1 in 90 3 million 3 million new cases annually estimated (NIAID)
199. Rotavirus 1.10% 1 in 90 3 million 3 million cases in the USA each year.
200. Von Willebrand disease 1.10% 1 in 90 3 million estimated 3 million mostly undiagnosed
201. Open-angle glaucoma 1.10% 1 in 90 3 million about 3 million Americans, many not yet diagnosed.
202. Peanut allergies 1.10% 1 in 90 3 million 3 million Americans (peanut and tree nut combined; NIAID)
203. Dental conditions 1.10% 1 in 90 2 million 1.1 per 100 (NHIS96: acute dental conditions)
204. Stuttering 1.00% 1 in 100 2.7 million about 1% of adults
205. Deuteranopia 1.00% 1 in 100 2.7 million about 1% of white males
206. Protanopia 1.00% 1 in 100 2.7 million about 1% of white males
207. Food allergies 1.00% 1 in 100 2.7 million 1% of the adult population have a true immune reaction to food (NHWIC)
208. Latex allergies 1.00% 1 in 100 2.7 million 1-6% (NIAID)
209. Speech impairment 1.00% 1 in 100 2.7 million 10 per 1000 (NHIS95)
210. Gastritis 0.99% 1 in 100 2.7 million 2.7 million people in the USA 1988 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
211. Rheumatoid arthritis 0.92% 1 in 108 2.5 million 2.5 million Americans (NWHIC); 1% of US population (NIAMS)
212. Campylobacter food poisoning 0.92% 1 in 108 2.5 million 2.5 million cases per year (CDC estimate/NIAID); 2 million cases to 8 million cases a year
213. Paralysis 0.90% 1 in 111 2.4 million 9 per 1000 - NHIS95 (paralysis of extremeties complete/partial)
214. Vision Impairment 0.88% 1 in 113 2.4 million 2.4 million Americans
215. Death 0.88% 1 in 113 2.4 million 2,391,399 annual deaths in 1999 (NVHS Sep 2001); annual risk of dying about 0.877% (NVSR 2001)
216. Epilepsy 0.85% 1 in 118 2.3 million 2.3 million Americans (CDC)
217. Uveitis 0.85% 1 in 118 2.3 million 2,300,000 people suffer uveitis in the US (Research to Prevent Blindness, NISE, NSF)
218. Congenital heart defects 0.83% 1 in 120 2.3 million 1 million (NHLBI)
219. Schizophrenia 0.81% 1 in 123 2.2 million Approximately 2.2 million American adults (NIMH); estimated 1.3% adults (USSG); more than 2 million Americans
220. Adverse reaction 0.81% 1 in 123 2.2 million 2.2 million adverse drug reactions after administration of FDA-approved drugs in USA 1996 (American Medical Association)
221. Deviated Septum 0.80% 1 in 124 2.2 million 8 per 1000 - NHIS95
222. Glaucoma 0.74% 1 in 136 2 million 2,000,000 people are visually impaired by glaucoma in the US (Research to Prevent Blindness, NISE, NSF)
223. Vitiligo 0.74% 1 in 136 2 million 2 to 5 million people in the USA (1-2% worldwide); 1,059,560 people in the USA 1996 1
224. Male infertility 0.74% 1 in 136 2 million at least 2 million annual cases (based on NWHIC)
225. Female infertility 0.74% 1 in 136 2 million at least 2 million annual cases (based on NWHIC)
226. Diverticular Disease 0.74% 1 in 136 2 million 2 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
227. Hepatitis C 0.74% 1 in 136 2 million estimated 2 to 5 million HCV chronic carriers
228. Alcoholic liver disease 0.74% 1 in 136 2 million More than 2 million Americans (NIAAA)
229. Emphysema 0.74% 1 in 136 2 million 2 million Americans (NHLBI); 17 per 1000 - NHIS95; 2 million annually
230. Nosocomial infections 0.74% 1 in 136 2 million estimated 2 million cases annually or about 10% of American hospital patients (CDC/NNIS 1992)
231. Atrial Fibrillation 0.74% 1 in 136 2 million 2 million (NHLBI)
232. Mycoplasma pneumoniae 0.74% 1 in 136 2 million estimated 2 million cases annually (DBMD)
233. Polymyalgia rheumatica 0.70% 1 in 142 1.9 million 700 per 100,000 people over 50.
234. Chronic tonsilitis 0.70% 1 in 142 1.9 million 7 per 1000 - NHIS95 (chronic disease of tonsils or adenoids)
235. Amputation 0.70% 1 in 142 1.9 million 7 per 1000 (NHIS95: excludes toes/fingers only)
236. Binge eating disorder 0.70% 1 in 142 1.9 million 0.7% to 4% of the general population (NWHIC); 2-5% of adults (NIMH); 2% of adults (NIDDK); 2% adults or 1-2 million adults (NWHIC)
237. Birth Injury 0.70% 1 in 142 1.9 million 7 per 1,000 births2.
238. Retina Conditions 0.66% 1 in 151 1.8 million 1,800,000 people have severely impaired vision because of retinal disease in the US (Research to Prevent Blindness, NISE, NSF)
239. Hepatitis B 0.55% 1 in 181 1.5 million estimated 1.5 million HBV carriers in the U.S. (NWHIC); 417,000 people currently infected (CDC 2001)
240. Fractures 0.55% 1 in 181 1.5 million 1.5 million osteoporosis-related fractures
241. Bulimia nervosa 0.55% 1 in 181 1.5 million estimated 1.1 to 4.2 percent of females (NIMH); 2-3% of young women (NWHIC)
242. Hashimoto's Thyroiditis 0.55% 1 in 182 1.5 million 1,490,371 adults and 205,159 children in the USA 1996 1
243. Lupus 0.51% 1 in 194 1.4 million 1.4 million people in the United States, 1 in 85 (NWHIC)
244. Salmonella food poisoning 0.51% 1 in 194 1.4 million estimated 1.4 million cases (CDC estimate/NIAID, many unreported)
245. Wegener's granulomatosis 0.50% 1 in 200 1.4 million uncommon
246. HTLV 0.50% 1 in 200 1.4 million uncommon
247. HTLV-1 0.50% 1 in 200 1.4 million uncommon
248. Peyronie's disease 0.50% 1 in 200 1.4 million 1 per 100 men
249. Sebaceous cyst 0.50% 1 in 200 1.4 million 5 per 1000 - NHIS95
250. Bladder Incontinence (Pregnancy) 0.49% 1 in 203 1.3 million 1-in-3 pregnant women approximately
251. Cancer 0.46% 1 in 217 1.2 million 1,248,900 annual cases (SEER 2002 estimate)
252. Medical misadventure 0.42% 1 in 238 1.1 million 1.14 million total patient safety incidents occurred among 37 million hospitalisations in the US 2000-02 (Patient Safety in American Hospitals, Health Grades 2004)
253. Blindness 0.40% 1 in 247 1.1 million 1,100,000 people are legally blind in the US (Research to Prevent Blindness, NISE, NSF)
254. Celiac Disease 0.40% 1 in 249 1.1 million 1 in 250 Americans estimated rate; actual diagnosis rate is 1 in 4,700 Americans; 1 in 250 in Italy; 1 in 300 in Ireland; 20,000 diagnosed (Reader's Digest Feb 2004)
255. Arm fracture 0.39% 1 in 255 1.1 million 17,819 annual cases in Victoria 1996 of radius/ulna (DHS-VIC)
256. Sports Injuries 0.38% 1 in 260 1 million 17,478 annual cases in Victoria 1996 (DHS-VIC)
257. Skin Cancer 0.37% 1 in 272 1 million more than 1 million annually (mostly the less dangerous types: basal and squamous)
258. Sjogren's Syndrome 0.37% 1 in 272 1 million 1 to 4 million people with Sjogren’s Syndrome (NIAMS)
259. Connective tissue disorders 0.37% 1 in 272 1 million estimated 1 million people in USA with heritable connective tissue disorder (NIAMS)
260. Genital warts 0.37% 1 in 272 1 million 1 million annual cases in the USA (NIAID)
261. Pelvic Inflammatory Disease 0.37% 1 in 272 1 million 1 million women have a PID episode each year (NIAID)
262. Aphasia 0.37% 1 in 272 1 million 1 million Americans (NINDS)
263. Kidney stones 0.37% 1 in 272 1 million more than 1 million cases (1996, NIDDK)
264. Hemochromatosis 0.37% 1 in 272 1 million more than 1 million Americans (CDC); 5 per 1000 in Caucasians (NIDDK); 1-in-200 to 1-in-300
265. Parkinson's Disease 0.37% 1 in 272 1 million 1 million people (unreliable estimate)
266. Dog bite 0.37% 1 in 272 1 million 1 million cases (unreliable estimate)
267. Heritable Disorders of Connective Tissue 0.37% 1 in 272 1 million estimated 1 million people in USA with heritable connective tissue disorder (NIAMS)
268. Ankle injuries 0.37% 1 in 272 1 million 1 million annually (NIAMS); 85% are ankle sprains.
269. Accidental Eye Injury 0.36% 1 in 277 978,987 16,413 annual cases in Victoria 1996 (DHS-VIC)
270. Selective IgA Deficiency 0.33% 1 in 300 906,666 1 in 300 (NIDCD); 1 in 600 (NIAID); 1 in 333 Caucasians.
271. HIV/AIDS 0.33% 1 in 302 900,000 900,000 Americans (NIAID, quarter are unaware)
272. Ankle sprain 0.31% 1 in 320 850,000 850,000 annually (NIAMS)
273. Interstitial cystitis 0.31% 1 in 321 847,000 847,000 in the USA 1988-1994 (Weighted Analysis of 1988-1994 National Health and Nutrition Survey, 2003)
274. Neuralgia 0.30% 1 in 333 816,000 3 per 1000 - NHIS95 (neuralgia or neuritis unspecified)
275. Scoliosis 0.30% 1 in 333 816,000 3-per-1,000 to 5-per-1000 children (NIAMS)
276. Gonorrhea 0.29% 1 in 339 800,000 800,000 cases (CDC estimate/NIAID)
277. Chronic Hepatitis B 0.28% 1 in 362 750,000 750,000 people in the United States (NIAID)
278. Gout 0.28% 1 in 363 748,000 275 per 100,000 people (NIAMS)
279. Spinal fracture 0.26% 1 in 388 700,000 more than 700,000 spinal fractures annually in the USA (the number caused by osteoporosis)
280. Poisoning 0.26% 1 in 391 694,829 11,649 annual cases in Victoria 1996 (DHS-VIC)
281. Edentulism 0.25% 1 in 400 681,706 11,429 annual cases in Victoria 1996 (DHS-VIC)
282. Von Hippel-Lindau Disease 0.25% 1 in 400 680,000 rare
283. Zollinger-Ellison syndrome 0.25% 1 in 400 680,000 rare
284. Lichen sclerosis 0.25% 1 in 400 680,000 rare
285. Immune Thrombocytopenic Purpura 0.25% 1 in 400 680,000 rare.
286. Behcet's Disease 0.25% 1 in 400 680,000 rare in the USA; more common in Middle East, Asia, and Japan.
287. Penile candidiasis 0.25% 1 in 400 680,000 rare
288. Ascariasis 0.25% 1 in 400 680,000 rare
289. Zellweger Syndrome 0.25% 1 in 400 680,000 rare
290. Congenital SMA with arthrogryposis 0.25% 1 in 400 680,000 rare
291. Agenesis of the corpus callosum 0.25% 1 in 400 680,000 rare
292. Aicardi syndrome 0.25% 1 in 400 680,000 rare
293. Empty Sella Syndrome 0.25% 1 in 400 680,000 rare
294. Hydranencephaly 0.25% 1 in 400 680,000 rare
295. Klippel Feil Syndrome 0.25% 1 in 400 680,000 rare
296. Mobius syndrome 0.25% 1 in 400 680,000 rare
297. Ataxia Telangiectasia 0.25% 1 in 400 680,000 rare
298. Chediak-Higashi Syndrome 0.25% 1 in 400 680,000 rare
299. Machado-Joseph Disease 0.25% 1 in 400 680,000 rare
300. Kearns-Sayre Syndrome 0.25% 1 in 400 680,000 rare
301. Alpers Syndrome 0.25% 1 in 400 680,000 rare
302. Agnosia 0.25% 1 in 400 680,000 rare
303. Alexander Syndrome 0.25% 1 in 400 680,000 rare
304. Alternating Hemiplegia 0.25% 1 in 400 680,000 rare
305. Binswanger's Disease 0.25% 1 in 400 680,000 rare
306. Brown-Sequard Syndrome 0.25% 1 in 400 680,000 rare
307. Canavan disease 0.25% 1 in 400 680,000 rare
308. Coffin-Lowry syndrome 0.25% 1 in 400 680,000 rare
309. Fabry's Disease 0.25% 1 in 400 680,000 rare
310. Fahr's Syndrome 0.25% 1 in 400 680,000 rare
311. Hallervorden-Spatz disease 0.25% 1 in 400 680,000 rare
312. Incontinentia Pigmenti 0.25% 1 in 400 680,000 rare
313. Joubert Syndrome 0.25% 1 in 400 680,000 rare
314. Krabbé Disease 0.25% 1 in 400 680,000 rare
315. Landau-Kleffner Syndrome 0.25% 1 in 400 680,000 rare
316. Microcephaly 0.25% 1 in 400 680,000 rare
317. Miller Fisher Syndrome 0.25% 1 in 400 680,000 rare
318. Moyamoya Disease 0.25% 1 in 400 680,000 rare
319. Parry Romberg Syndrome 0.25% 1 in 400 680,000 rare
320. Pelizaeus-Merzbacher Disease 0.25% 1 in 400 680,000 rare
321. Primary Lateral Sclerosis 0.25% 1 in 400 680,000 rare
322. Progressive Supranuclear Palsy 0.25% 1 in 400 680,000 rare
323. Rasmussen's Encephalitis 0.25% 1 in 400 680,000 rare
324. Sandhoff Disease 0.25% 1 in 400 680,000 rare
325. Schilder's Disease 0.25% 1 in 400 680,000 rare
326. Septo-Optic Dysplasia 0.25% 1 in 400 680,000 rare
327. Soto's Syndrome 0.25% 1 in 400 680,000 rare
328. Stiff-Person Syndrome 0.25% 1 in 400 680,000 rare
329. Subacute Sclerosing Panencephalitis 0.25% 1 in 400 680,000 rare - because of the rarity of measles due to vaccination programs.
330. Williams Syndrome 0.25% 1 in 400 680,000 rare
331. Ménétrier's disease 0.25% 1 in 400 680,000 rare
332. Acute Appendicitis 0.25% 1 in 400 680,000 25 per 10,000 (age 10-17), 1-2 per per 10,000 (under 4)
333. Goodpasture syndrome 0.25% 1 in 400 680,000 rare.
334. Encephaloceles 0.25% 1 in 400 680,000 rare
335. Ramsay Hunt Syndrome Type 2 0.25% 1 in 400 680,000 rare
336. Mastocytosis 0.25% 1 in 400 680,000 rare
337. Cutaneous mastocytosis 0.25% 1 in 400 680,000 rare
338. Restrictive cardiomyopathy 0.25% 1 in 400 680,000 rare
339. Pulmonary embolism 0.24% 1 in 418 650,000 approximately 650,000 cases annually in the USA
340. Bacterial vaginosis 0.24% 1 in 424 640,000 16% of pregnant women (DSTD)
341. Gall bladder conditions 0.23% 1 in 438 620,031 10,395 annual cases of gallbladder and bile duct disease in Victoria 1996 (DHS-VIC)
342. Caesarian Section 0.22% 1 in 453 600,000 more than 600,000 annually
343. Polycystic kidney disease 0.22% 1 in 453 600,000 600,000 Americans
344. Hysterectomy 0.22% 1 in 461 590,000 590,000 annually
345. Inflammatory bowel disease 0.20% 1 in 500 544,000 1 in 500 (NIAID); 300,000 people to 500,000 people NIDDK
346. Klinefelter syndrome 0.20% 1 in 500 544,000 1-in-500 to 1-in-1000 male births (NIDCD)
347. Congenital hip dislocation 0.20% 1 in 500 544,000 about 2 per 1000 births; up to 4 per 1000
348. Sickle Cell Anemia 0.20% 1 in 500 544,000 72,000 people in USA (NHLBI); 2 million carriers (USA); 1 in 12 African American carriers
349. Autism 0.20% 1 in 500 544,000 1 in 500 to 1 in 2,500 (NIMH); 1-in-1000 to 2-in-1000, depending on diagnostic criteria
350. Nonaffective Psychosis 0.20% 1 in 500 544,000 estimated 0.2% adults (USSG)
351. Somatization Disorder 0.20% 1 in 500 544,000 estimated 0.2% adults (USSG)
352. Postpartum psychosis 0.20% 1 in 500 544,000 1 in 500 to 1,000 new mothers
353. Cerebral Palsy 0.20% 1 in 500 544,000 2 to 2.5 per 1,000 births (FMC)
354. Traumatic Brain Injury 0.20% 1 in 500 544,000 0.2% of population has an acquired brain injury in Australia 1998 (Australia’s Health 2004, AIHW)
355. Temporal arteritis 0.20% 1 in 500 544,000 200 per 100,000 people over 50.
356. Intussusception 0.20% 1 in 500 544,000 about 2 per 1000 cases in infants
357. Hypertrophic cardiomyopathy 0.20% 1 in 500 544,000 0.2 percent of the U.S. population
358. Sudden Infant Death Syndrome 0.20% 1 in 500 544,000 2 per 1,000
359. Autosomal dominant polycystic kidney disease 0.20% 1 in 503 540,000 540,000 Americans approximately (90% of PKD)
360. Hand fracture 0.20% 1 in 507 536,287 8,991 annual cases in Victoria 1996 (DHS-VIC)
361. Crohn's disease 0.18% 1 in 544 500,000 500,000 Americans
362. Chronic Fatigue Syndrome 0.18% 1 in 544 500,000 500,000 Americans (CDC/NIAID)
363. Shingles 0.18% 1 in 544 500,000 500,000 cases (NIAID)
364. Inguinal hernia 0.18% 1 in 544 500,000 500,000 cases (NIDDK)
365. Pneumococcal pneumonia 0.18% 1 in 544 500,000 500,000 cases annually (NIAID)
366. Bedsores 0.17% 1 in 573 474,692 474,692 new cases of decubitus ulcer occurred in the US 2000-2002 (Patient Safety in American Hospitals, Health Grades 2004)
367. Viral Hepatitis 0.17% 1 in 601 452,000 about 452,000 annual cases based on incidence of HepA, HepB, HepC, and HepD (NIDDK 1990-1992)
368. Chronic Nonulcer dyspepsia 0.16% 1 in 612 444,000 444,000 new cases (1975/NIDDK)
369. Premature Birth 0.16% 1 in 618 440,000 440,000 cases (unreliable estimate)
370. Benign Prostate Hyperplasia 0.16% 1 in 627 433,216 7,263 annual cases in Victoria 1996 (DHS-VIC)
371. Liver conditions 0.15% 1 in 679 400,000 400,000 people in the USA 1976-80 for "chronic liver disease and cirrhosis" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
372. Postpartum depression 0.15% 1 in 679 400,000 10% of pregnancies.
373. Chronic liver disease 0.15% 1 in 679 400,000 400,000 people
374. Cirrhosis of the liver 0.15% 1 in 679 400,000 400,000 people in the USA 1976-80 for "chronic liver disease and cirrhosis" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
375. Ocular Herpes 0.15% 1 in 679 400,000 400,000 Americans have had some form
376. Pernicious anemia 0.15% 1 in 680 399,454 399,455 people in the USA 1996 1
377. End-stage renal disease 0.14% 1 in 693 392,022 392,023 people in the USA 2001 (United States Renal Data System 2003 Annual Data Report, 2003)
378. Multiple Sclerosis 0.14% 1 in 700 388,571 1-in-700 (NIAID)
379. Triple-X syndrome 0.14% 1 in 700 388,571 1-in-700 approximately.
380. Cleft palate 0.14% 1 in 700 388,571 about 1 in 700 births
381. Dementia 0.14% 1 in 738 368,320 6,175 annual cases in Victora 1996 (DHS-VIC)
382. Intestinal obstruction 0.13% 1 in 746 364,563 6,112 annual cases in Victoria 1996 (DHS-VIC)
383. Burns 0.13% 1 in 754 360,507 6,044 annual cases in Victora 1996 for fires/burns/scalds (DHS-VIC)
384. Ankylosing Spondylitis 0.13% 1 in 775 350,879 129 of every 100,000 people in the US (Mayo Clinic)
385. Type 1 diabetes 0.12% 1 in 800 340,000 1-in-800 (NIAID)
386. Down Syndrome 0.12% 1 in 800 340,000 1-in-800 overall births
387. Genital system cancer 0.12% 1 in 841 323,210 323,210 new cases for genital system cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
388. Neural tube defect 0.12% 1 in 864 314,703 11.57 per 10,000 births with neural tube defects in the UK 2002 (University of Ulster, 2003)
389. Shoulder Fracture 0.12% 1 in 867 313,624 5,258 annual cases in Victoria 1996 of clavicle/scapula/humerus (DHS-VIC)
390. Scleroderma 0.11% 1 in 906 300,000 estimated 300,000 Americans (NWHIC)
391. Hip fracture 0.11% 1 in 906 300,000 more than 300,000 hip fractures annually (the number due to osteoporosis)
392. Machinery accidents 0.11% 1 in 942 288,453 4,836 annual cases in Victoria 1996 (DHS-VIC)
393. Kidney Dialysis 0.11% 1 in 946 287,493 287,494 people in the USA 2001 (United States Renal Data System 2003 Annual Data Report, 2003)
394. Natural accidents 0.10% 1 in 958 283,800 4,758 annual cases in Victoria 1996 of natural/environmental factors (DHS-VIC)
395. Anorexia Nervosa 0.10% 1 in 1,000 272,000 estimated 0.1% adults (USSG); estimated 0.5 to 3.7 percent females (NIMH); 1% of adolescent girls (NWHIC)
396. Clubfoot 0.10% 1 in 1,000 272,000 about 1 per 1,000 births2.
397. Ankle fracture 0.10% 1 in 1,048 259,524 4,351 annual cases in Victoria 1996 (DHS-VIC)
398. Face fracture 0.09% 1 in 1,063 255,826 4,289 annual cases in Victoria 1996 (DHS-VIC)
399. Digestive system cancer 0.09% 1 in 1,063 255,640 255,640 new cases for digestive system cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
400. Wrist fracture 0.09% 1 in 1,088 250,000 at least 250,000 wrist fractures (the number caused by osteoporosis annually in the USA)
401. Fractured femur 0.09% 1 in 1,155 235,486 3,948 annual cases in Victoria 1996 (DHS-VIC)
402. Foot fracture 0.08% 1 in 1,240 219,262 3,676 annual cases in Victoria 1996 (DHS-VIC)
403. Fractured Lower Leg 0.08% 1 in 1,304 208,466 3,495 annual cases in Victoria 1996 (DHS-VIC)
404. Breast Cancer 0.08% 1 in 1,326 205,000 205,000 annual cases (SEER 2002 estimate); 180,000 annual cases (NCI); only about 1,000 men
405. Narcolepsy 0.07% 1 in 1,359 200,000 200,000 Americans (NHLBI estimate); 50,000 diagnosed.
406. Prostate Cancer 0.07% 1 in 1,439 189,000 189,000 annual cases in USA (SEER 2002 estimate); 168,665 new cases (NIDDK)
407. Respiratory system cancer 0.07% 1 in 1,458 186,550 186,550 new cases for respiratory system cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
408. Norwalk-like viruses 0.07% 1 in 1,502 181,000 estimated 181,000 cases annually in USA (CDC-OC)
409. Aortic aneurysm 0.07% 1 in 1,537 176,913 2,966 annual cases in Victoria 1996 (DHS-VIC)
410. Hydrocephalus 0.06% 1 in 1,547 175,711 6.46 per 10,000 births in the UK 2002 for hydrocephaly (University of Ulster, 2003)
411. Lung cancer 0.06% 1 in 1,605 169,400 169,400 annual cases (SEER 2002 estimate: lung and bronchus cancers)
412. Adult respiratory distress syndrome 0.06% 1 in 1,813 150,000 150,000 adults (NHLBI)
413. Colorectal cancer 0.05% 1 in 1,834 148,300 148,300 annual cases = 107,300 annual cases of colon cancer and 41,000 annual cases of rectum cancer(SEER 2002 estimate)
414. Preeclampsia 0.05% 1 in 1,858 146,320 146,320 cases (1998/NHLBI); about 5% of pregnancies.
415. Méničre's disease 0.05% 1 in 1,973 137,847 about 10,000 people in Australia
416. Autoimmune Lymphoproliferative Syndrome 0.05% 1 in 2,000 136,000 very rare; NIAID mentions 58 individuals
417. Neonatal lupus 0.05% 1 in 2,000 136,000 very rare
418. Jacobs syndrome 0.05% 1 in 2,000 136,000 1-in-2000 approximately.
419. Androgen Insensitivity Syndrome 0.05% 1 in 2,000 136,000 very rare
420. Porencephaly 0.05% 1 in 2,000 136,000 extremely rare
421. Schizencephaly 0.05% 1 in 2,000 136,000 extremely rare
422. Keratoconus 0.05% 1 in 2,000 136,000 1-in-2000 Americans
423. Gestational diabetes 0.05% 1 in 2,014 135,000 135,000 pregnant women get the condition every year; 3-5% of pregnant women.
424. Chickenpox 0.04% 1 in 2,254 120,624 120,624 annually (1995); 46,016 annual cases notified in USA 1999 (MMWR 1999); 199.14 per 100,000 in Canada 20003
425. Hip Replacement 0.04% 1 in 2,266 120,000 120,000 annually (NIAMS); 120,000 annual hip replacement operations in the USA.
426. Whiplash 0.04% 1 in 2,266 120,000 120,000 annually
427. Carbon monoxide poisoning 0.04% 1 in 2,400 113,333 25,000 annual cases of home exposure in the UK
428. Lyme disease 0.04% 1 in 2,719 100,000 estimated 100,000 cases annually (NIAID/USA)
429. Hyperparathyroidism 0.04% 1 in 2,719 100,000 100,000 cases per year in the USA
430. Retinitis Pigmentosa 0.04% 1 in 2,719 100,000 100,000 people have retinitis pigmentosa which can cause retinal deterioration and blindness in the US (Research to Prevent Blindness, NISE, NSF)
431. Urinary system cancer 0.04% 1 in 2,764 98,400 98,400 new cases for urinary system cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
432. Septicemia 0.04% 1 in 2,767 98,300 1,648 annual cases in Victora 1996 (DHS-VIC)
433. Accidental death 0.03% 1 in 2,906 93,591 93,592 annual cases in 2000 (CDC); 97,860 annual cases in 1999 (NVSR Sep 2001)
434. Edwards Syndrome 0.03% 1 in 3,000 90,666 1-in-3000 approximately.
435. Velocardiofacial syndrome 0.03% 1 in 3,000 90,666 1-in-3000 approximately.
436. Fragile-X Syndrome 0.03% 1 in 3,000 90,666 about 1 in 1500 males4.
437. Familial emphysema 0.03% 1 in 3,000 90,666 70,000 Americans
438. Neurofibromatosis 0.03% 1 in 3,000 90,666 about 1 in 30004.
439. Suffocation 0.03% 1 in 3,285 82,790 1,388 annual cases in Victoria 1996 of suffocation and foreign bodies (DHS-VIC)
440. Vagina cancer 0.03% 1 in 3,333 81,600 3 in 10,000 for DES-related cases of vaginal cancer.
441. Diethylstilbestrol 0.03% 1 in 3,333 81,600 3 per 10,000 with a risk of vaginal cancer; probably higher if include other complications of DES
442. Acute Pancreatitis 0.03% 1 in 3,400 80,000 80,000 cases occur in the USA (NIDDK); 17 per 100,000 new cases
443. Vertebral fracture 0.03% 1 in 3,619 75,155 1,260 annual cases in Victoria 1996 (DHS-VIC)
444. Heroin dependence 0.03% 1 in 3,692 73,664 1,235 annual cases in Victoria 1996 (DHS-VIC)
445. Escherichia coli O157:H7 0.03% 1 in 3,726 73,000 estimated 73,000 annual cases of infection in USA (DBMD)
446. Cannabis dependence 0.03% 1 in 3,759 72,351 1,213 annual cases in Victoria 1996 (DHS-VIC)
447. Sedative dependence 0.03% 1 in 3,759 72,351 1,213 annual cases in Victoria 1996 (DHS-VIC)
448. Syphilis 0.03% 1 in 3,885 70,000 70,000 cases (NIAID; CDC 2001)
449. Ectopic pregnancy 0.03% 1 in 3,885 70,000 70,000 cases annually; about 1 in 250 pregnancies.
450. Hepatitis D 0.03% 1 in 3,885 70,000 70,000 new cases in the USA 1990 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
451. Congenital hypothyroidism 0.03% 1 in 4,000 68,000 about 1 in 4000 babies
452. Diabetic Retinopathy 0.02% 1 in 4,184 65,000 65,000 diabetics develop proliferative retinopathy, the most sight-threatening stage in the US (Research to Prevent Blindness, NISE, NSF)
453. Holoprosencephaly 0.02% 1 in 4,201 64,736 2.38 per 10,000 births in the UK 2002 for arhinencephaly/holprosencephaly (University of Ulster, 2003)
454. Multiple Myeloma 0.02% 1 in 4,317 63,000 about 63,000 people affected by multiple myeloma ("Orphan Products: Hope for People With Rare Diseases", By Carol Rados, FDA Consumer magazine, November-December 2003 Issue)
455. Primary Glomerulonephritis 0.02% 1 in 4,428 61,422 61,423 people with Primary Glomerulonephritis in the USA 1996 1
456. IgA nephropathy 0.02% 1 in 4,428 61,422 61,423 people in the USA 1996 1
457. Lymphoma 0.02% 1 in 4,466 60,900 60,900 annual cases in USA (SEER 2002 estimate)
458. Pelvic fracture 0.02% 1 in 4,475 60,780 1,019 annual cases in Victoria 1996 (DHS-VIC)
459. Bladder Cancer 0.02% 1 in 4,814 56,500 56,500 annual cases in USA (SEER 2002 estimate)
460. Patau syndrome 0.02% 1 in 5,000 54,400 1-in-5000 approximately.
461. Turner Syndrome 0.02% 1 in 5,000 54,400 1-in-5000
462. Sarcoidosis 0.02% 1 in 5,000 54,400 20 per 100,000 overall; 5 in 100,000 white people; 40 out of 100,000 black people; Scandinavia 64 out of 100,000 people
463. Aortic coarctation 0.02% 1 in 5,000 54,400 1 in 5000 babies
464. Marfan syndrome 0.02% 1 in 5,000 54,400 1 in 5,000 people in the USA
465. Ehlers-Danlos syndrome 0.02% 1 in 5,000 54,400 1 in 5,000 to 10,000 (Ehler's Danlos National Foundation)
466. Non-Hodgkin's Lymphoma 0.02% 1 in 5,046 53,900 53,900 annual cases in USA (SEER 2002 estimate)
467. Melanoma 0.02% 1 in 5,074 53,600 53,600 annual cases (SEER 2002 estimate: skin melanomas)
468. Cardiomyopathy 0.02% 1 in 5,439 50,000 50,000 Americans (NHLBI)
469. Pancreatitis 0.02% 1 in 5,882 46,240 17 new cases per 100,000 in the USA 1976-88 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
470. Duchenne Muscular Dystrophy 0.02% 1 in 6,000 45,333 about 1 in 3000 males4.
471. Giardia 0.02% 1 in 6,138 44,308 16.29 per 100,000 in Canada 20003
472. Skull fracture 0.02% 1 in 6,413 42,409 711 annual cases in Victoria 1996 (DHS-VIC)
473. Diabetes Insipidus 0.01% 1 in 6,666 40,800 less than 15 per 100,000 hospitalized patients
474. Coccidioidomycosis 0.01% 1 in 6,666 40,800 15 cases per 100,000 population in Arizona in 1995 (DBMD)
475. Rectal cancer 0.01% 1 in 6,704 40,569 40,570 new cases for rectum cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
476. Bell's Palsy 0.01% 1 in 6,800 40,000 40,000 annual cases in Americans
477. Neonatal Respiratory Distress Syndrome 0.01% 1 in 6,800 40,000 40,000 infants and 150,000 adults with adult RDS (NHLBI)
478. Endometrial Cancer 0.01% 1 in 6,921 39,300 39,300 annual cases in USA (SEER 2002 estimate)
479. Prolactinoma 0.01% 1 in 7,142 38,080 less than 14 per 100,000 (the rate for pituitary tumors)
480. Pituitary Cancer 0.01% 1 in 7,142 38,080 14 per 100,000 people (NIDDK)
481. Hepatitis A 0.01% 1 in 8,500 32,000 32,000 new cases in the USA 1992 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
482. Kidney Cancer 0.01% 1 in 8,553 31,800 31,800 annual cases in USA (SEER 2002 estimate); more than 28,000 cases annually in the United States
483. Leukemia 0.01% 1 in 8,831 30,800 30,800 annual cases in USA (SEER 2002 estimate) including 10,800 lymphocytic, 15,000 myeloid and 5,000 other leukemias; about 29,000 cases annually (NCI); nearly 27,000 adults and more than 2,000 children annually.
484. Pancreatic cancer 0.01% 1 in 8,976 30,300 30,300 annual cases (SEER 2002 estimate)
485. Amyotrophic lateral sclerosis 0.01% 1 in 9,066 30,000 30,000 cases of ALS in America (Robert Packard Research Center at John Hopkins Hospital)
486. Cystic Fibrosis 0.01% 1 in 9,066 30,000 30,000 Americans (NIDDK)
487. Suicide 0.01% 1 in 9,315 29,200 29,199 annual cases of actual suicide in 1999 USA (NVHS Sep 2001)
488. Oral cancer 0.01% 1 in 9,411 28,900 28,900 annual cases (SEER 2002 estimate)
489. Firearm Injury 0.01% 1 in 9,420 28,873 28,874 annual cases causing death in 1999 USA (NVSR Sep 2001)
490. Tuberous sclerosis 0.01% 1 in 10,000 27,200 less than 1 in 10,000
491. Autoimmune Thrombocytopenia 0.01% 1 in 10,000 27,200 less than 10 per 100,000 cases and 1-4 per 100,000 in children1
492. Phenylketonuria 0.01% 1 in 10,000 27,200 1 of every 10,000 infants in the United States (NIDCD)
493. Rett's syndrome 0.01% 1 in 10,000 27,200 1 in 10,000-15,000 live female births
494. Osteogenesis imperfecta 0.01% 1 in 10,000 27,200 about 1 in 10,0004.
495. Endocrine system cancer 0.01% 1 in 10,658 25,520 25,520 new cases for endocrine system cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
496. E-coli food poisoning 0.01% 1 in 10,879 25,000 25,000 cases per year estimated
497. Meningitis 0.01% 1 in 10,879 25,000 approximately 25,000 cases of bacterial meningitis annually in USA; 206 annual cases in Victoria 1996 (DHS-VIC)
498. Fetal alcohol syndrome 0.01% 1 in 11,111 24,479 0.9 per 10,000 births (Caucasians); Asians 0.3, Hispanics 0.8, African Americans 6.0, and Native Americans 29.9 (NWHIC).
499. Amputated thumb 0.01% 1 in 11,573 23,500 394 annual cases in Victoria 1996 (DHS-VIC)
500. Ovarian Cancer 0.01% 1 in 11,673 23,300 23,300 annual cases in USA (SEER 2002 estimate); about 1 in 57 women in the United States (NCI)
501. Invasive candidiasis 0.01% 1 in 12,500 21,760 8 per 100,000 for candidemia (DBMD)
502. Stomach cancer 0.01% 1 in 12,592 21,600 21,600 annual cases (SEER 2002 estimate); about 24,000 annual cases in the United States (NCI)
503. Amputated finger 0.01% 1 in 13,066 20,816 349 annual cases in Victoria 1996 (DHS-VIC)
504. Thyroid cancer 0.01% 1 in 13,140 20,700 20,700 annual cases in USA (SEER 2002 estimate); 19,500 annual cases in the USA (NCI); 14,900 women and 4,600 men annually (NCI).
505. Uterine Cancer 0.01% 1 in 13,333 20,400 4,500 women in the UK 2001 (National Statistics, UK Government Census, 2001)
506. Ross River virus 0.01% 1 in 13,513 20,128 7.4 new cases per 100,000 population of Ross River Virus infection was notified in Australia 2002 (Yohannes K, Roche P, Blumer C et al. 2004, Australia’s Health 2004, AIHW)
507. Hemophilia 0.01% 1 in 13,600 20,000 20,000 people in the United States (NHLBI)
508. Placenta previa 0.01% 1 in 13,600 20,000 1 in 200 pregnancies (FMC)
509. Transplants 0.01% 1 in 14,315 19,000 more than 19,000 transplants annually in USA (NIAID)
510. Group B Streptococcal Infections 0.01% 1 in 14,492 18,767 6.9 cases per 100,000 (DBMD)
511. Tuberculosis 0.01% 1 in 14,814 18,360 18,361 cases annually in the USA (1998); 8 million people worldwide develop active TB and 3 million die; 17,531 annual cases notified in USA 1999 (MMWR 1999); 5.50 per 100,000 in Canada 20003
512. Rabies 0.01% 1 in 15,111 18,000 18,000 cases (of rabies shots rather than actual rabies)
513. Shigellosis 0.01% 1 in 15,524 17,521 17,521 annual cases of shigellosis notified in USA 1999 (MMWR 1999)
514. Brain cancer 0.01% 1 in 16,000 17,000 17,000 annual cases in USA (SEER 2002 estimate: brain and other nervous system)
515. Homicide 0.01% 1 in 16,105 16,889 16,889 annual cases in 1999 including 10,828 for firearms (NVSR Sep 2001)
516. Liver cancer 0.01% 1 in 16,385 16,600 16,600 annual cases (SEER 2002 estimate)
517. Spina bifida 0.01% 1 in 16,666 16,320 6 per 100,000 births
518. Usher Syndrome 0.01% 1 in 17,000 16,000 16,000 Americans
519. Kidney transplant 0.01% 1 in 17,741 15,331 15,331 procedures in the USA 2001 (United States Renal Data System 2003 Annual Data Report, 2003)
520. Myelodysplastic syndromes 0.01% 1 in 19,428 14,000 14,000 people are diagnosed with myelodysplastic syndrome each year in the US (American Cancer Society, Medical News Today)
521. Myasthenia Gravis 0.00% 1 in 20,000 13,600 about 5 per 100,000 to 14 per 100,000 (NWHIC)
522. Dermatomyositis 0.00% 1 in 20,205 13,461 13,462 people with polymyositis/dermatomyositis in the USA 1996 1
523. Cervical Cancer 0.00% 1 in 20,923 13,000 13,000 annual cases in USA (SEER 2002 estimate)
524. Barmah Forest virus 0.00% 1 in 21,739 12,512 4.6 new cases per 100,000 population of Barmah Forest Virus infection was notified in Australia 2002 (Yohannes K, Roche P, Blumer C et al. 2004, Australia’s Health 2004, AIHW)
525. Larynx Cancer 0.00% 1 in 22,666 12,000 12,000 annual cases in the United States (NCI); 8,900 annual cases (SEER 2002 estimate)
526. Acute myeloid leukemia 0.00% 1 in 22,818 11,919 11,920 new cases for Acute Myeloid Leukemia in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
527. Rheumatic heart disease 0.00% 1 in 23,505 11,571 194 annual cases in Victoria 1996 (DHS-VIC)
528. Acromegaly 0.00% 1 in 25,000 10,880 40-60 per million affected people at any time
529. Q fever 0.00% 1 in 25,641 10,608 3.9 new cases per 100,000 population of Q Fever were notified in Australia 2002 (Yohannes K, Roche P, Blumer C et al. 2004, Australia’s Health 2004, AIHW)
530. Mouth cancer 0.00% 1 in 26,984 10,080 10,080 new cases for mouth cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
531. Toxocariasis 0.00% 1 in 27,200 10,000 estimated 10,000 annual cases in USA (DPD)
532. Avascular necrosis 0.00% 1 in 27,200 10,000 10,000 to 20,000 annual cases (NIAMS)
533. Primary biliary cirrhosis 0.00% 1 in 29,462 9,231 9,232 people in the USA 1996 1
534. Viral meningitis 0.00% 1 in 30,452 8,932 8,932 new cases in America 1995 (Meningitis Foundation of America, CDC, 1994)
535. Group A Streptococcal Infections 0.00% 1 in 31,249 8,704 3.2 cases per 100,000 (DBMD)
536. Soft Tissue Sarcoma 0.00% 1 in 32,771 8,300 8,300 annual cases (SEER 2002 estimate)
537. Pharynx cancer 0.00% 1 in 32,969 8,250 8,250 new cases for pharynx cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
538. Chronic lymphocytic leukemia 0.00% 1 in 33,211 8,190 8,190 new cases for Chronic Lymphocytic Leukemia in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
539. Colonic volvulus 0.00% 1 in 33,333 8,160 3 per 100,000 persons per year
540. Multiple endocrine neoplasia type 1 0.00% 1 in 33,333 8,160 3 per 100,000 up to 20 per 100,000 (NIDDK)
541. Testicular Cancer 0.00% 1 in 36,266 7,500 7,500 annual cases in USA (SEER 2002 estimate)
542. Whooping Cough 0.00% 1 in 36,731 7,405 7,405 cases annually in USA (1998); under-diagnosis of cases in adults means the real prevalence may be much higher
543. Tongue Cancer 0.00% 1 in 37,158 7,320 7,320 new cases for tongue cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
544. Gall Bladder Cancer 0.00% 1 in 38,309 7,100 7,100 annual cases (SEER 2002 estimate: gallbladder and other biliary)
545. Hodgkin's Disease 0.00% 1 in 38,857 7,000 7,000 annual cases in USA (SEER 2002 estimate); less than 1 percent of all cases of cancer
546. Infant Cytomegalic virus 0.00% 1 in 45,333 6,000 6,000 babies
547. Motor neuron diseases 0.00% 1 in 49,566 5,487 92 annual cases in Victoria 1996 (DHS-VIC)
548. Small Intestine Cancer 0.00% 1 in 51,320 5,300 5,300 annual cases (SEER 2002 estimate)
549. Bronchopulmonary dysplasia 0.00% 1 in 54,400 5,000 5,000 to 10,000 new cases
550. Brainerd diarrhea 0.00% 1 in 54,400 5,000 estimated 5,000-8,000 patients (DBMD)
551. Reiter’s syndrome 0.00% 1 in 57,142 4,760 3.5 per 100,000 men under age 50 get Reiter’s syndrome each year
552. Autoimmune uveitis 0.00% 1 in 58,658 4,637 4,637 people in the USA 1996 1
553. Chronic myeloid leukemia 0.00% 1 in 59,130 4,600 4,600 new cases for Chronic Myeloid Leukemia in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
554. Corneal Dystrophies 0.00% 1 in 64,761 4,200 4,200 people have reduced vision because of corneal dystrophies in the US (Research to Prevent Blindness, NISE, NSF)
555. Anencephaly 0.00% 1 in 68,000 4,000 less than 4,000 cases (the rate for spina bifida and anencephaly, NWHIC)
556. Anal Cancer 0.00% 1 in 69,743 3,900 3,900 annual cases (SEER 2002 estimate)
557. Acute lymphocytic leukemia 0.00% 1 in 71,018 3,830 3,830 new cases for Acute Lymphocytic Leukemia in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
558. Vulva cancer 0.00% 1 in 71,578 3,800 3,800 annual cases in USA (SEER 2002 estimate)
559. Autoimmune Hemolytic Anemia 0.00% 1 in 80,000 3,400 1 per 80,000 cases to 2.6 per 100,000 (as reported in Rose and Mackay 19985)
560. Amyloidosis 0.00% 1 in 90,666 3,000 less than 3,000 people in the US (Mayo Clinic)
561. Addison's Disease 0.00% 1 in 100,000 2,720 1 in 100,000; 13,335 people in the USA 1996 1
562. Guillain-Barre Syndrome 0.00% 1 in 100,000 2,720 about 1 in 100,000 (NWHIC)
563. Mycobacterium avium Complex 0.00% 1 in 100,000 2,720 1 per 100,000 annually (DBMD)
564. Aspergillosis 0.00% 1 in 100,000 2,720 1-2 per 100,000 per year (DBMD)
565. X-Linked Agammaglobulinemia 0.00% 1 in 100,000 2,720 1-in-100,000
566. Yersiniosis 0.00% 1 in 100,000 2,720 approx 1 per 100,000 annually (DBMD); 19 cases in NJ 1998 (NJ DHSS)
567. Pneumococcal meningitis 0.00% 1 in 100,000 2,720 about 1 to 2 per 100,000 in the USA
568. Cushing's syndrome 0.00% 1 in 100,000 2,720 2-5 per million (NIDCD); 10 per million; 10-15 per million
569. Drowning 0.00% 1 in 100,000 2,720 1 per 100,000 population drowns in Australia 2002 (Australia’s Health 2004, AIHW)
570. Blastomycosis 0.00% 1 in 100,000 2,720 1-2 cases per 100,000 (DBMD)
571. Infant Death 0.00% 1 in 102,719 2,648 2,648 annual cases (NVSR Sep 2001); 7.1 per 1,000 infant deaths (per births) in USA 1999 (NVSR Sep 2001)
572. Mesothelioma 0.00% 1 in 106,571 2,552 563 new cases in the UK 2002(UK Government Statistics)
573. Meningococcal disease 0.00% 1 in 108,756 2,500 2,501 annual cases notified in USA 1999 (MMWR 1999)
574. Listeriosis 0.00% 1 in 108,800 2,500 estimated 2,500 annually in USA (DBMD)
575. Amputated toe 0.00% 1 in 111,223 2,445 41 annual cases in Victoria 1996 (DHS-VIC)
576. Bone cancer 0.00% 1 in 113,333 2,400 2,400 annual cases (SEER 2002 estimate: bones and joints)
577. Ureter cancer 0.00% 1 in 113,333 2,400 2,400 annual cases in USA (SEER 2002 estimate)
578. Invasive group A Streptococcal disease 0.00% 1 in 114,189 2,382 2,382 annual cases notified in USA 1999 (MMWR 1999); 1.95 per 100,000 in Canada 20003
579. Cryptosporiosis 0.00% 1 in 115,205 2,360 2,361 annual cases notified in USA 1999 (MMWR 1999)
580. Eye cancer 0.00% 1 in 123,636 2,200 2,200 annual cases (SEER 2002 estimate: eye and orbit)
581. Amebiasis 0.00% 1 in 150,800 1,803 54 cases in NJ 1998 (NJ DHSS)
582. Malaria 0.00% 1 in 151,111 1,800 1,800 cases annually (1997); 1,666 annual cases notified in USA 1999 (MMWR 1999)
583. Huntington's Disease 0.00% 1 in 175,390 1,550 26 annual cases in Victoria 1996 (DHS-VIC)
584. Cryptococcal Meningitis 0.00% 1 in 200,000 1,360 about 5 per million
585. Unexplained Illness 0.00% 1 in 200,000 1,360 At least 0.5 cases per 100,000 (DBMD)
586. Penis Cancer 0.00% 1 in 226,666 1,200 1,200 annual cases in USA (SEER 2002 estimate)
587. Autoimmune Hepatitis 0.00% 1 in 235,294 1,156 1,156 people in the USA 1996 1
588. Legionnaires' disease 0.00% 1 in 245,487 1,107 1,108 annual cases notified in USA 1999 (MMWR 1999)
589. Kawasaki disease 0.00% 1 in 271,440 1,002 30 cases in NJ 1998 (NJ DHSS)
590. Thalassemia 0.00% 1 in 272,000 1,000 1,000 people with Cooley's anemia (NHLBI)
591. Vibrio parahaemolyticus 0.00% 1 in 400,000 680 0.25 per 100,000 (DBMD 1997)
592. Necrotizing fasciitis 0.00% 1 in 453,333 600 600 cases (DBMD)
593. Rocky Mountain spotted fever 0.00% 1 in 469,775 578 579 annual cases notified in USA 1999 (MMWR 1999)
594. Congenital syphilis 0.00% 1 in 489,208 556 556 annual cases notified in USA 1999 (MMWR 1999)
595. Cryptococcosis 0.00% 1 in 500,000 544 0.2-0.9 cases per 100,000 in the general population (DBMD)
596. SCID 0.00% 1 in 500,000 543 approximately 1-per-500,000 (NIDCD); 1-per-million
597. Amputated arm 0.00% 1 in 506,683 536 9 annual cases in Victoria 1996 (DHS-VIC)
598. Lymphangioleiomyomatosis 0.00% 1 in 544,000 500 Several hundred people in the USA (NHLBI)
599. Nocardiosis 0.00% 1 in 544,000 500 estimated 500-1,000 annual cases in USA (DBMD)
600. Muscular Dystrophy 0.00% 1 in 651,450 417 7 annual cases in Victoria 1996 (DHS-VIC)
601. Maternal death 0.00% 1 in 695,652 391 391 women in 1999 (NVSR Sep 2001)
602. Mumps 0.00% 1 in 702,842 387 387 annual cases notified in USA 1999 (MMWR 1999); rare due to MMR vaccination
603. Rubella 0.00% 1 in 747,252 364 364 cases annually (1998); incidence greatly reduced by MMR vaccination programs
604. Typhoid fever 0.00% 1 in 786,127 346 346 annual cases notified in USA 1999 (MMWR 1999)
605. Ehrlichiosis 0.00% 1 in 900,662 301 302 annual cases (203 of human granulocytic ehrlichiosis and 99 of human monocytic ehrlichiosis) notified in USA 1999 (MMWR 1999)
606. Vibrio vulnificus 0.00% 1 in 906,666 300 less than 300 cases in 1988-1995 (DBMD)
607. Primary pulmonary hypertension 0.00% 1 in 906,666 300 300 new cases annually (NHLBI)
608. Granuloma inguinale 0.00% 1 in 1 million 272 0.1 new cases per 100,000 population of donovanosis was notified in Australia 2002 (Yohannes K, Roche P, Blumer C et al. 2004, Australia’s Health 2004, AIHW)
609. Arbovirus 0.00% 1 in 1 million 272 0.1 new cases per 100,000 population of arbovirus infection was notified in Australia 2002 (Yohannes K, Roche P, Blumer C et al. 2004, Australia’s Health 2004, AIHW)
610. Hepatitis E 0.00% 1 in 1 million 272 0.1 new cases per 100,000 population of Hepatitis E was notified in Australia 2002 (Yohannes K, Roche P, Blumer C et al. 2004, Australia’s Health 2004, AIHW)
611. Creutzfeldt-Jakob Disease 0.00% 1 in 1 million 271 1-per-million
612. Hemophilus influenzae B 0.00% 1 in 1 million 260 261 annual cases of invasive HIB in USA 1999 (MMWR 1999)
613. Vibrio 0.00% 1 in 1.2 million 233 7 cases in NJ 1998 (NJ DHSS)
614. Babesiosis 0.00% 1 in 1.2 million 233 7 cases in NJ 1998 (NJ DHSS)
615. Hemolytic uremic syndrome 0.00% 1 in 1.3 million 201 202 cases of postdiarrheal HUS in 28 USA states 2001 (Morbidity and Mortality Weekly Report, 2003)
616. Mucopolysaccharidosis I 0.00% 1 in 1.4 million 200 about 200 people ("Orphan Products: Hope for People With Rare Diseases", By Carol Rados, FDA Consumer magazine, November-December 2003 Issue)
617. Botulism food poisoning 0.00% 1 in 1.8 million 153 154 annual cases notified in USA 1999 including 23 foodborne, 92 infant, and 39 other (MMWR 1999)
618. Chancroid 0.00% 1 in 1.9 million 143 143 annual cases notified in USA 1999 (MMWR 1999); rare in the USA but with occasional outbreaks.
619. Toxic Shock Syndrome 0.00% 1 in 2.4 million 112 113 annual cases notified in USA 1999 (MMWR 1999); 1-2 per 100,000 (DBMD)
620. Leprosy 0.00% 1 in 2.5 million 108 108 annual cases notified in USA 1999 (MMWR 1999)
621. Glucagonoma 0.00% 1 in 2.7 million 100 only 100 cases since 1974 (Ganda, 1997)
622. Leptospirosis 0.00% 1 in 2.7 million 100 100-200 cases annually in USA (DBMD)
623. Measles 0.00% 1 in 2.7 million 100 100 cases annually (1998); once common, now greatly reduced by MMR vaccination programs; 100 annual cases notified in USA 1999 (MMWR 1999)
624. Dengue fever 0.00% 1 in 2.7 million 100 about 100 to 200 cases annually in USA (NIAID)
625. POEMS 0.00% 1 in 2.7 million 100 about 100 known cases (Ganda [1997])
626. Infant botulism food poisoning 0.00% 1 in 2 million 92 92 annual cases notified in USA 1999 (MMWR 1999)
627. Brucellosis 0.00% 1 in 3.3 million 82 82 annual cases notified in USA 1999 (MMWR 1999)
628. Pregnancy-associated osteoporosis 0.00% 1 in 3.4 million 80 80 annual cases (NWHIC)
629. Encephalitis, California serogroup viral 0.00% 1 in 3.9 million 70 70 annual cases notified in USA 1999 (MMWR 1999)
630. Chronic Granulomatous Disease 0.00% 1 in 4 million 67 1-in-4 million to 5 million (NIAID)
631. Streptococcal Toxic Shock Syndrome 0.00% 1 in 4.5 million 61 61 annual cases notified in USA 1999 (MMWR 1999)
632. Cyclosporiasis 0.00% 1 in 4.9 million 55 56 annual cases notified in USA 1999 (MMWR 1999)
633. Rheumatic conditions 0.00% 1 in 6.3 million 43 nearly 43 Americans have arthritis or a rheumatic disease (CDC); 40 million people in the United States (NIAMS)
634. Tetanus 0.00% 1 in 6.8 million 40 40 annual cases notified in USA 1999 (MMWR 1999); rare due to vaccination.
635. Hantavirus 0.00% 1 in 8.2 million 32 33 annual cases of Hantavirus pulmonary syndrome notified in USA 1999 (MMWR 1999)
636. Marine toxins 0.00% 1 in 9.1 million 29 approximately 30 cases annually in USA (DBMD)
637. Baylisascaris 0.00% 1 in 9.1 million 29 fewer than 30 cases have been reported (DPD)
638. East African Trypanosomiasis 0.00% 1 in 12 million 21 21 cases in USA (DPD)
639. Somatostatinoma 0.00% 1 in 13.6 million 20 20 known cases in the literature (Ganda, 1997)
640. Psittacosis 0.00% 1 in 17 million 16 16 annual cases notified in USA 1999 (MMWR 1999)
641. Trichinosis 0.00% 1 in 22.7 million 11 12 annual cases notified in USA 1999 (MMWR 1999)
642. Plague 0.00% 1 in 30.2 million 9 9 annual cases of plague notified in USA 1999 (MMWR 1999)
643. Rubella congenital syndrome 0.00% 1 in 30.2 million 9 9 annual cases notified in USA 1999 (MMWR 1999)
644. Cholera 0.00% 1 in 45.3 million 5 6 annual cases notified in USA 1999 (MMWR 1999)
645. Gastrointestinal Basidiobolomycosis 0.00% 1 in 45.3 million 5 6 cases ever in history (CDC-OC)
646. Eastern equine encephalitis 0.00% 1 in 54.4 million 5 5 annual cases notified in USA 1999 (MMWR 1999)
647. St. Louis encephalitis 0.00% 1 in 68 million 4 4 annual cases notified in USA 1999 (MMWR 1999)
648. Respiratory diphtheria 0.00% 1 in 100 million 2 Approximately 0.001 per 100,000 in USA (DBMD)
649. Cutaneous diphtheria 0.00% 1 in 100 million 2 Approximately 0.001 cases per 100,000 population in the U.S. since 1980 (DBMD)
650. Hydatidiform mole 0.00% 1 in 272 million 1 about 1 in 2000 pregnancies
651. Diphtheria 0.00% 1 in 272 million 1 1 annual case notified in USA 1999 (MMWR 1999)
652. Yellow fever 0.00% 1 in 272 million 1 1 annual case notified in USA 1999 (MMWR 1999)
653. Pseudotumor Cerebri 0.00% 1 in 272 million 1 about 1-2 people per 100,000 population have benign intracranial hypertension in the US (Association for Spina Bifida and Hydrocephalus)
654. Japanese encephalitis 0.00% 1 in 272 million 1 1 case annually in USA (DVBID)
655. Western equine encephalitis 0.00% 1 in 272 million 1 1 annual cases notified in USA 1999 (MMWR 1999)
656. Melioidosis 0.00% 1 in never 0 0-5 cases annually (DBMD)
657. Anthrax 0.00% 1 in never 0 0 annual cases notified in USA 1999 (MMWR 1999)
658. Polio 0.00% 1 in never 0 0 annual cases of paralytic poliomyelitis notified in USA 1999 (MMWR 1999)
659. Smallpox 0.00% 1 in never 0 0 cases throughout the world.
660. Lymphatic Filariasis 0.00% 1 in never 0 about 0 cases in the USA (DPD)
661. Kuru 0.00% 1 in never 0 0%; the disease is almost extinct.
662. Glanders 0.00% 1 in never 0 0 cases (CDC)
663. Viral Hemorrhagic Fevers 0.00% 1 in never 0 0 new cases of viral haemorrhagic fever per 100,000 population was notified in Australia 2002 (Yohannes K, Roche P, Blumer C et al. 2004, Australia’s Health 2004, AIHW)


Footnotes:
1. Rose and Mackay, 1998, The Autoimmune Diseases, Third Edition
2. Childhood Symptoms, Edward R. Brace, John P. Pacanowski, Ed Weiner, 1992
3. Notifiable Diseases Online, PPHB, Canada, 2000
4. Pathophysiology of Disease, Stephen J. McPhee, Vishwanash R. Lingappa, Willim F. Ganong, Jack D. Lang, Prentice Hall, 1995
5. The Autoimmune Diseases, Noel R. Rose, Ian R. Mackay, 1998

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