Conditions by Undiagnosed Prevalence

Conditions here are listed according to undiagnosed prevalence, which is the estimated number of people who unknowingly have the condition, but have not been diagnosed. For comparison, see conditions by people affected (prevalence or incidence), conditions by prevalence and conditions by incidence. See also details about prevalence and incidence statistics for more information. In most cases, the rates refer to the USA or other industrialized nations.

Condition	Percent	Rate	US People	Data
1. Toxoplasmosis	22.06%	1 in 4	60 million	less than 60 million; most do not have symptoms (DPD)
2. Sleep disorders	14.71%	1 in 6	40 million	about 40 million (almost all cases are undiagnosed according to some reports)
3. Otosclerosis	10.00%	1 in 10	27.2 million	as many as 10% of Caucasians have the condition but most do not get symptoms.
4. Extra Nipples	10.00%	1 in 10	27.2 million	about 1 in 10 people have an extra nipple but most are small, misshapen, and mistaken for freckles or moles
5. Osteoporosis	6.62%	1 in 15	18 million	18 million with low bone mass (many are undiagnosed)
6. Hypertension	5.51%	1 in 18	15 million	more than 15 million (more than 30% of 50 million are undiagnosed)
7. Chronic lower respiratory diseases	5.51%	1 in 18	15 million	estimated 15 million
8. Chronic Obstructive Pulmonary Disease	5.51%	1 in 18	15 million	15 million undiagnosed or in early stages
9. Migraine	5.15%	1 in 19	14 million	14 million undiagnosed
10. Thyroid disorders	4.78%	1 in 20	13 million	about 13 million (based on estimates from the AACE, as reported by Reader's Digest ¹; estimated 8 million people (American Medical Women's Association)
11. Latent tuberculosis	3.68%	1 in 27	10 million	estimated 10 to 15 million people in USA (NIAID)
12. Obstructive sleep apnea	3.68%	1 in 27	10 million	as many as 10 million
13. Diabetes	2.10%	1 in 47	5.7 million	5.7 million Americans (based on NWHIC)
14. Sleep apnea	2.00%	1 in 50	5.4 million	estimated 2-4% of Americans undiagnosed
15. Chlamydia	1.25%	1 in 80	3.4 million	estimated 3.4 million cases (based in NIAID/CDC estimates with only about 600,000 to 800,000 reported from 4 million cases)
16. Parkinson's Disease	1.10%	1 in 90	3 million	estimated 3-4 million people
17. Age-related macular degeneration	0.83%	1 in 120	2.3 million	0.5 million in the UK
18. Sjogren's Syndrome	0.74%	1 in 136	2 million	estimated 2 million
19. Aneurysm	0.74%	1 in 136	2 million	about 2 million Americans with unruptured brain aneurysms (Reader's Digest Feb 2004)¹
20. Hemochromatosis	0.55%	1 in 181	1.5 million	1.5 million Americans (Hemochromatosis Foundation)
21. Salmonella food poisoning	0.51%	1 in 194	1.4 million	up to 1.4 million cases (CDC/NAID); estimated that only 2% of cases are reported to CDC
22. Breast Cancer	0.37%	1 in 272	1 million	estimated 1 million
23. Glaucoma	0.37%	1 in 272	1 million	1 to 1.5 million (about half of 3 million Americans) for chronic glaucoma
24. Celiac Disease	0.37%	1 in 272	1 million	estimated 1 million undiagnosed Americans; more than a million (Reader's Digest Feb 2004)
25. Von Willebrand disease	0.37%	1 in 272	1 million	estimated 1 million undiagnosed US women with Von Willebrand disease
26. Open-angle glaucoma	0.37%	1 in 272	1 million	1 to 1.5 million (about half of 3 million Americans)
27. Cryptosporiosis	0.18%	1 in 544	500,000	0.5 to 2 million undiagnosed cases each year
28. Gonorrhea	0.15%	1 in 679	400,000	estimated 400,000 cases (CDC/NIAID based on 800,000 estimates with about 400,000 reported)
29. HIV/AIDS	0.08%	1 in 1,208	225,000	estimated 225,000 Americans (based on NIAID 900,000 prevalence with quarter undiagnosed).
30. Narcolepsy	0.06%	1 in 1,813	150,000	estimated 150,000 undiagnosed (based on NHLBI estimates)

Footnotes:
1. Reader's Digest, February 2004, "10 Diseases Doctors Miss", page 120

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