Cure Research for Preeclampsia


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Research discussion: Furthermore, a small trial of antioxidant therapy (1,000 mg vitamin C and 400 IU of vitamin E) resulted in a reduced incidence of preeclampsia when begun at 22 weeks gestation in women at high risk for the syndrome. Thus, the closest thing to a treatment target in the field is anti-oxidant therapy based on this collection of hypotheses and data. However, effectiveness in large populations and, even more importantly, safety for the fetus, are not established. 1

Treatment and prevention trials have been disappointing to date. However, several recent studies have suggested causal links between oxidative stress, depletion of vitamin C, low levels of the endogenous vasodilator nitric oxide, and the development of preeclampsia, suggest that there may be a role for anti-oxidant vitamins in the prevention of preeclampsia. A clinical trial should be undertaken testing the hypothesis that anti-oxidant vitamins can reduce the risk of preeclampsia, reduce maternal and fetal mortality, and increase birthweight. Such a trial, and all other clinical trials, also should incorporate study of biomarkers and other measures of risk factors and determine predictors and early pathophysiological changes of preeclampsia in low-risk and high-risk populations. A protocol for a similar trial has been developed in the National Institute of Child Health and Human Development's (NICHD) Maternal-Fetal Medicine Units Network and the possibility of a collaborative arrangement of the NHLBI with NICHD in conducting such a trial should be explored. It might be effective to utilize this same resource for a study for the treatment of preexisting hypertension in pregnancy. 1

Medical research for Preeclampsia: medical news summaries: The following medical news items are relevant to medical research for Preeclampsia:



Footnotes:
1. excerpt from REPORT of the WORKING GROUP on RESEARCH on HYPERTENSION DURING PREGNANCY: NHLBI

Last revision: June 12, 2003

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