Basic Summary for X-Linked Agammaglobulinemia

Main name of condition: X-Linked Agammaglobulinemia
Other names or spellings: XLA, Bruton type agammaglobulinemia, X-linked infantile agammaglobulinemia, congenital agammaglobulinemia

What is X-Linked Agammaglobulinemia?
  Brief description of X-Linked Agammaglobulinemia: Immune deficiency from lack of antibodies.
  Parent types of X-Linked Agammaglobulinemia: Primary Immune Deficiency, Immune disorders, Immune deficiency conditions, Genetic Disease, Recessive Genetic Diseases, X-linked Genetic Diseases, X-linked Recessive Genetic Diseases, Carrier conditions, X Chromosome Disorders
  Organs Affected by X-Linked Agammaglobulinemia: immune system, white blood cells, x chromosome

How many people get X-Linked Agammaglobulinemia?
  Prevalance of X-Linked Agammaglobulinemia: 1-in-100,000
  Prevalance Rate of X-Linked Agammaglobulinemia: approx 1 in 100,000 or 0.00% or 2,720 people in USA [about data]
  Prevalance of X-Linked Agammaglobulinemia: One out of 100,000 people have XLA.¹

Who gets X-Linked Agammaglobulinemia?
  Patient Profile for X-Linked Agammaglobulinemia: Infants. Symptoms develop early.
  Gender Profile for X-Linked Agammaglobulinemia: Boys only (X-linked recessive).
  Gender Profile for X-Linked Agammaglobulinemia: Only boys get XLA. That is because girls have two sets of X chromosomes, and the normal copy compensates for the faulty gene. ¹

How serious is X-Linked Agammaglobulinemia?
Complications of X-Linked Agammaglobulinemia: see complications of X-Linked Agammaglobulinemia

What causes X-Linked Agammaglobulinemia?
  Cause of X-Linked Agammaglobulinemia: Genetic defect in the gene producing a protein called btk for B-cell development.
  Causes of X-Linked Agammaglobulinemia: Alternations in a gene found on the X chromosome cause XLA. This gene normally produces a protein called btk, which is required for B-cell development.¹
  Class of Condition for X-Linked Agammaglobulinemia: genetic x-linked recessive
  Causes of X-Linked Agammaglobulinemia: see causes of X-Linked Agammaglobulinemia

What are the symptoms of X-Linked Agammaglobulinemia?
Symptoms of X-Linked Agammaglobulinemia: see symptoms of X-Linked Agammaglobulinemia

Can anyone else get X-Linked Agammaglobulinemia?
Inheritance: see inheritance of X-Linked Agammaglobulinemia
Inheritance of genetic conditions: see details in inheritance of genetic diseases.

How is it treated?
Treatments for X-Linked Agammaglobulinemia: see treatments for X-Linked Agammaglobulinemia

Footnotes:
1. excerpt from Primary Immune Deficiency, NIAID Fact Sheet: NIAID

Medical Tools & Articles:

Next articles:

Medical Articles: